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. 2014 Feb;95(2):215–224. doi: 10.1189/jlb.0313180

Figure 5. The protective CTL response is focused around the large airways early after reinfection.

Figure 5.

B6 mice received 103 naive OTI cells, 48 h before i.n. or i.p. infection with WSN-OVAI. One (IN-1 and IP-1) or 7 (IN-7) months later, the mice were challenged with X31-OVA. Fragments of fixed lung tissue were stained 3 and 6 dpi using antibodies to EpCAM (red), CD45.1 (green), and CD31 (blue). Z-Stack images were taken at normal magnification, ×20. Representative fields from groups of three to six animals are shown. (A) Cross-sections of large airways. (B) Cross-sections of large blood vessels. (C) Lung parenchyma.