Figure 3.

The relationship between median IC₅₀ values of quinine (QN), mefloquine (MQ) and chloroquine (CQ) and the mutations of pfmdr1 and pfmrp1 gene in Plasmodium falciparum isolates. Association between (A) QN IC₅₀ and pfmdr1 N86Y (p = 0.015, Mann–Whitney U test), S1034C (p = 0.018, Kruskal-Wallis test) and pfmrp1 F1390I mutation (p = 0.039, Mann–Whitney U test); (B) MQ IC₅₀ and pfmdr1 N86Y mutation (p = 0.005, Mann–Whitney U test); and (C) CQ IC₅₀ and pfmrp1 H191Y mutation (p = 0.008, Mann–Whitney U test).