Table 1.
In vitro sensitivity of Plasmodium falciparum isolates (represented by IC 50 values) to chloroquine (CQ), quinine (QN), mefloquine (MQ), and artesunate (AS) and their sensitivity classification
| Drug | Sensitivity classification | % (n) | IC 50 , nM |
|---|---|---|---|
| AS |
All |
100 (119) |
2.0 (1.7–2.3) |
| Sensitive (IC50 ≤2.3 nM) |
58.0 (69) |
1.4 (1.8–2.8) |
|
| Declined sensitivity (IC50 >2.3 nM) |
42.0 (50) |
3.4 (3.1–3.7) |
|
| MQ |
All |
100 (119) |
30.1 (21.8–33.3) |
| Sensitive |
42.0 (50) |
15.2 (12.8–17.6) |
|
| Resistant |
58.0 (69) |
54.1 (46.8–61.4) |
|
| CQ |
All |
100 (119) |
72.3 (67.3–77.3) |
| Sensitive |
0.8 (1) |
9.6 |
|
| Moderate resistant |
73.1 (87) |
66.6 (63.5–69.7) |
|
| Highly resistant |
26.1 (31) |
131.6 (118.9–144.4) |
|
| QN | All |
100 (119) |
231.7 (192.2–271.2) |
| Sensitive |
86.6 (103) |
222.6 (195.5–249.8) |
|
| Resistant | 13.4 (16) | 648.9 (621.2–676.5) |
Data presented as median (95% CI) and percentage (number).