Table 1.
PhenX Toolkit measures employed in the current study and availability/comparability of PMRP data for validation
| PhenX ID | PhenX measure name | Available PMRP data source for comparison | Comparability of measures (N/A for not applicable where there are no data for comparison) |
|---|---|---|---|
| 010101 |
Current age |
EMR |
Not identical but expect congruence because construct is same |
| 010201 |
Birthplace |
No data |
N/A |
| 010301 |
Birthplace of parents |
No data |
N/A |
| 010401 |
Birthplace of grandparents |
No data |
N/A |
| 010501 |
Ethnicity |
Enrollment questionnaire (US Census question) |
Fewer forced options were available on the PMRP questionnaire then the PhenX questionnaire based on expected responses prior to the “other/please specify” option. Construct is the same. |
| 010601 |
Race |
Enrollment questionnaire (US Census question) |
Fewer forced options were available on the PMRP questionnaire then the PhenX questionnaire based on expected responses prior to the “other/please specify” option. Construct is the same. |
| 010701 |
Gender |
EMR |
Not identical but expect congruence because construct is same |
| 010801 |
Current address |
EMR |
Not identical but expect congruence because construct is same |
| 010901 |
Current marital status |
No data |
N/A |
| 011001 |
Current educational attainment |
Questionnaire for subset post enrollment |
Not identical but expect congruence because construct is same, fewer forced categories for lower levels of education in PMRP questionnaire based on expected responses |
| 011301 |
Current employment status |
Enrollment questionnaire (US Census question) |
Similar construct, but not identical questions. PhenX includes 8 choices for current working status. PMRP questionnaire asked about being employed in the previous 5 years (yes/no) |
| 011401 |
Household roster – relationships |
No data |
N/A |
| 011501 |
Health insurance coverage |
EMR |
Not identical but expect congruence because construct is same |
| 020602 |
Hand dominance (12 years and older) |
No data |
N/A |
| 020704 |
Self-reported height |
Measured at enrollment, EMR |
Same construct, but expect some over-reporting based on literature |
| 021502 |
Self-reported weight |
Measured at enrollment, EMR |
Same construct, but expect some under-reporting based on literature |
| 030101 |
Alcohol – lifetime use |
No data |
N/A |
| 030201 |
Alcohol – age of first use |
No data |
N/A |
| 030301 |
Alcohol – 30-day frequency and quantity |
Enrollment questionnaire |
Same construct, but PhenX did not have forced category responses. PhenX had open-ended number of days and number of drinks per day. PMRP had forced categories of response (<1, 1–2, 3–4, 5–7 days per week and 1, 2, 3–4, 50 or more drinks per day) |
| 030401 |
Alcohol – maximum drinks in 24 hours |
No data |
N/A |
| 030501 |
Alcohol – lifetime abuse and dependence |
No data |
N/A |
| 030602 |
Tobacco – smoking status (adult protocol) |
Enrollment questionnaire |
Identical questions |
| 030702 |
Tobacco – age of initiation of use (adult protocol) |
No data |
N/A |
| 030802 |
Tobacco – 30-day quantity and frequency (adult protocol) |
Enrollment questionnaire |
Identical questions |
| 030902 |
Tobacco – age of offset of use (adult protocol) |
No data |
N/A |
| 031001 |
Tobacco – nicotine dependence |
No data |
N/A |
| 040101 |
Family history of heart attack |
Family history of heart or stroke from enrollment questionnaire |
Similar construct but definition of relatives is different and two health outcomes were included in the PMRP questionnaire |
| 060101 |
Characteristics of current residence |
No data |
N/A |
| 060701 |
Current environmental tobacco smoke exposure |
No data |
N/A |
| 060801 |
Sibship/birth order |
No data |
N/A |
| 061301 |
Ultraviolet light exposure |
No data |
N/A |
| 070301 |
Passive smoke exposure |
No data |
N/A |
| 120402 |
Hypomania/mania symptoms - adult |
No data |
N/A |
| 120502 |
Depression – adult |
No data |
N/A |
| 130301 |
History of stroke – ischemic infarction and hemorrhage |
EMR |
Similar construct but difficult to determine if people completing PhenX questionnaire understand medical terms |
| 150901 | Total physical activity screener | No comparable data | N/A |