Table 1.
Differentially methylated sites in young versus old monocyte cell populations
| Target ID | β-difference* | Adjusted p-value | Gene |
|---|---|---|---|
|
cg10501210 |
−0.38 |
0.002884 |
miR-29b-2
*
*
|
|
cg24892069 |
−0.30 |
0.00312 |
NRP1 |
|
cg27209729 |
−0.30 |
0.020571 |
NRXN2 |
| cg11807280 |
−0.27 |
0.013523 |
|
| cg08128734 |
−0.27 |
0.015965 |
RASSF5 |
| cg11693709 |
−0.26 |
0.024853 |
PAK6 |
| cg18826637 |
−0.25 |
0.022927 |
|
| cg00329615 |
−0.25 |
0.012874 |
IGSF11 |
| cg00740914 |
−0.25 |
0.008061 |
|
| cg03873281 |
−0.25 |
0.005647 |
PDLIM4 |
| cg13039251 |
−0.23 |
0.008793 |
PDZD2 |
| cg07583137 |
−0.23 |
0.007904 |
CHMP4C |
| cg12317815 |
−0.22 |
0.014773 |
ASPA |
| cg06781608 |
−0.22 |
0.030063 |
PTPRN2 |
| cg13001142 |
−0.22 |
0.011913 |
STXBP5 |
| cg16932827 |
−0.21 |
0.015062 |
|
| cg19344626 |
−0.21 |
0.010547 |
NWD1 |
| cg14295611 |
−0.21 |
0.04857 |
|
| cg14614643 |
−0.21 |
0.008462 |
|
| cg03915012 |
−0.21 |
0.026415 |
GAK |
| cg03473532 |
−0.20 |
0.035003 |
MKLN1 |
| cg02978201 |
0.47 |
0.015062 |
PRM1 |
| cg04875128 |
0.30 |
0.017558 |
OTUD7A |
| cg21184711 |
0.23 |
0.024671 |
CADPS2 |
| cg20665157 |
0.22 |
0.008629 |
CADPS2 |
| cg19907915 | 0.21 | 0.014934 | IGSF9B |
The three replicated CpG loci are shown in bold.
*A negative β-difference indicates to hypomethylation in the elderly and a positive β-difference indicates to hypermethylation in the elderly population. Only CpG sites with FDR-adjusted p-values less than 0.05 were considered differentially methylated.
**Approximately 1 kb upstream.