Table 1.
Clinical severity scale of immediate reactions
| According to ring and messmer [17] | According to NCI-CTCAE | |
|---|---|---|
| Grade |
Clinical signs |
|
| 1 |
Cutaneous-mucous signs |
Mild transient reaction with no infusion interruption |
| 2 |
Cutaneous-mucous signs |
Therapy or infusion interruption indicated but responds promptly to symptomatic treatment (antihistamines, corticosteroids, narcotics, IV fluids) |
| Cardiovascular signs (tachycardia, hypotension) | ||
| Respiratory signs | ||
| 3 |
Cardiovascular collapse |
Prolonged reaction not rapidly responsive to symptomatic medication and/or brief interruption of infusion. |
| Bronchospam |
Recurrence of symptoms following initial improvement |
|
| Hospitalization indicated for clinical sequelae | ||
| 4 |
Cardiac arrest |
Life-threatening consequences with urgent intervention indicated |
| 5 | - | Death |
NCI-CTCAE: National Cancer Institute Common Terminology Criteria for Adverse Events.