. Author manuscript; available in PMC: 2015 Feb 1.

Published in final edited form as: Am J Ophthalmol. 2013 Oct 22;157(2):318–326. doi: 10.1016/j.ajo.2013.10.004

Table 2.

Natamycin and Voriconazole Minimum Inhibitory Concentration Values From a Fungal Keratitis Clinical Trial

Organism	N	Natamycin (μg/mL)			Voriconazole (μg/mL)

		MIC₅₀ (95% CI)^b	MIC₉₀^a (95% CI)^b	MIC Range	MIC₅₀ (95% CI)^b	MIC₉₀^a (95% CI)^b	MIC Range
Identified hyaline	178	4	32	1 to 64	2	8	0.25 to 16
Fusarium species	126	4 (4 to 4)	8 (4 to 8)	2 to 32	4 (4 to 4)	8 (8 to 16)	0.25 to 16
Aspergillus species	52	32 (16 to 32)	64 (32 to 64)	1 to 64	0.5 (0.5 to 0.5)	2 (1-4)	0.25 to 8
A. flavus	32	32 (32 to 32)	64 (32 to 64)	2 to 64	0.5 (0.5 to 0.5)	2 (1-4)	0.25 to 8
A. fumigatus	10	4 (2 to 4)	64 (4 to 64)	2 to 64	0.5 (0.25 to 0.5)	1.3 (0.5 to 4)	0.25 to 4
A. niger	2	5	ND	2 to 8	3	ND	2 to 4
A. terreus	3	16	ND	8 to 16	0.5	ND	0.5 to 0.5
Other	5	4	ND	1 to 32	0.5	ND	0.5 to 2
Unidentified hyaline	4	4	ND	2 to 8	0.75	ND	0.03 to 8

Identified dematiaceous	34	2	2	1 to 16	0.5	2	0.25 to 8
Curvularia species	17	2 (2 to 2)	2 (2 to 16)	1 to 16	0.25 (0.25 to 0.5)	4 (0.5 to 8)	0.25 to 8
Exserohilum species	8	2	ND	1 to 2	1	ND	0.5 to 2
Alternaria species	2	2	ND	2 to 2	1	ND	1 to 1
Bipolaris species	4	2	ND	2 to 2	0.25	ND	0.25 to 1
Lasiodiplodia species	3	2	ND	2 to 2	0.5	ND	0.5 to 2
Unidentified dematiaceous	3	4	ND	2 to 4	1	ND	0.25 to 2
Other species	2	2	ND	2 to 2	8.25	ND	0.5 to 16

Total	221	4	32	1 to 64	2	8	0.03 to 16
P-Value			<0.001^c			<0.001^c

Abbreviations: N, number; ND, not determined; MIC, minimum inhibitory concentration; CI, confidence interval; MIC₅₀, minimum inhibitory concentration median; MIC₉₀, minimum inhibitory concentration 90^th percentile.

MIC₉₀ estimated for genus or species with at least 9 isolates, the smallest number where extrapolation would not be necessary.

Estimation of 95% CI only performed for genus or species with at least 9 isolates

Analysis of variance test (ANOVA) comparing MIC values among genera