Table 3.
Prior Ocular Susceptibility Studies With Minimum Inhibitory Concentrations to Natamycin, Voriconazole or Amphotericin B against Fusarium and Aspergillus species
| Studya | Species (Number of Isolates) |
Natamycin (μg/mL) | Voriconazole (μg/mL) | Amphotericin B (μg/mL) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||
| MIC50 | MIC90 | MIC Range | MIC50 | MIC90 | MIC Range | MIC50 | MIC90 | MIC Range | ||
| Debourgogne et al., 201222 |
F. solani (48) | – | – | – | – | 8 | 1 to 16 | – | 2 | 0.13 to 2 |
|
| ||||||||||
| Edelstein et al., 201223 | F. solani (1) | – | – | 16 | – | – | 8 | – | – | 4 |
|
| ||||||||||
| Giaconi et al., 200616 | Fusarium spp. (1) | – | – | – | – | – | 8 | – | – | – |
|
| ||||||||||
| Homa et al., 201317 | Fusarium spp. (60) | 8c | >64c | 2 to >64 | 64c | >64c | 0.13 to >64 | 16c | >64c | 0.13 to >64 |
| F. solani (43) | 8c | >64c | 2 to >64 | 64c | >64c | 0.13 to >64 | 8c | 64c | 0.13 to >64 | |
| F. non-solani (17) | 8c | >64c | 2 to >64 | 64c | >64c | 16 to >64 | 16c | >64c | 4 to >64 | |
|
| ||||||||||
| Iqbal et al., 20089 | Fusarium spp. (85) | – | – | 4 to 16 | – | – | 0.5 to >8 | – | – | 0.5 to >8 |
| F. solani (57) | 8 | – | 4 to 16 | >8 | – | 8 to >8 | 2 | – | 0.5 to >8 | |
| F. non-solani (35) | – | – | 4 to 8 | – | – | 0.5 to >8 | – | – | 1 to 4 | |
|
| ||||||||||
| Kondori et al., 201118 | Fusarium spp. (5) | – | – | – | – | – | 0.25 to >8 | – | – | – |
| F. solani (1) | – | – | – | – | – | −>8 | – | – | – | |
| F. non-solani (4) | – | – | – | – | – | 0.25 to 1 | – | – | – | |
|
| ||||||||||
| Lalitha et al., 20076 | Fusarium spp. (38) | 8 | 16 | – | 2 | 4 | – | 4 | 4 | – |
|
| ||||||||||
| Lalitha et al., 200819 | Fusarium spp. (41) | 4 | 4 | 2 to 8 | – | – | – | – | – | – |
|
| ||||||||||
| Lalitha et al., 20127 | Fusarium spp. (44) | 4 | 8 | 2 to 16 | 4 | 16 | 2 to 16 | – | – | – |
|
| ||||||||||
| Li et al., 200820 | Fusarium spp. (38) | 4 | 16 | 2 to 16 | – | – | – | 4 | 4 | 2 to 16 |
|
| ||||||||||
| Oechsler et al., 20138 | F. solani (NAT 44, VRC 15, AMB 43) |
4.8 | 4.8 | 2.4 to 9.6 | 16 | 16 | 4 to ≥16 | 2 | 2 | 1 to ≥16 |
| F. non-solani (NAT 14, VRC 12, AMB 14) |
2.4 | 4.8 | 2.4 to 4.8 | 4 | 4 | 2 to ≥16 | 2 | 2 | 1 to 2 | |
|
| ||||||||||
| Ozdemir et al., 201213 | Fusarium spp. (9) | – | – | – | 4c | 8c | 1 to 8 | 1c | 2c | 0.5 to 2 |
| F. solani (2) | – | – | – | 4c | – | 4 to 8 | 1c | – | 1 to 2 | |
| F. non-solani (7) | – | – | – | 4c | – | 1 to 4 | 0.5c | – | 0.5 to 2 | |
|
| ||||||||||
| Pradhan et al., 201112, d | Fusarium spp. (15) | – | – | 4 to 8 | – | – | – | – | – | – |
|
| ||||||||||
| Shapiro et al., 201011 | Fusarium spp. (23) | 8 | 16 | 4 to 16 | – | – | – | – | – | – |
|
| ||||||||||
| Sponsel et al., 200224, b | F. solani (1) | – | – | 32 | – | – | – | – | – | 2 |
|
| ||||||||||
| Taylan et al., 201225 | F. solani (1) | – | – | – | – | – | 8 | – | – | 0.5 |
|
| ||||||||||
| Tu et al., 200726 | F. solani (1) | – | – | – | – | – | 8 | – | – | 4 |
|
| ||||||||||
| Wang et al., 200921 | Fusarium spp. (71) | – | – | – | – | – | – | 0.5 | 1 | 0.06 to 1 |
|
| ||||||||||
| Xie et al., 200827 | F. solani (34) | – | – | – | – | – | – | 1 | 2 | – |
|
| ||||||||||
| Total Range | Fusarium spp. | 4 to 8 |
4 to
>64 |
2 to >64 |
2 to
64 |
4 to
>64 |
0.13 to >64 |
0.5 to
16 |
1 to
>64 |
0.06 to
>64 |
|
| ||||||||||
| F. solani |
4.8 to
8 |
4.8 to
>64 |
2 to >64 |
4 to
64 |
8 to
>64 |
0.13 to >64 | 1 to 8 |
2 to
64 |
0.13 to
>64 |
|
|
| ||||||||||
| F. non-solani |
2.4 to
8 |
4.8 to
>64 |
2 to >64 |
4 to
64 |
4 to
>64 |
0.25 to >64 |
0.5 to
16 |
2 to
>64 |
0.5 to >64 | |
|
| ||||||||||
| Kondori et al., 201118 | Aspergillus spp. (29) | – | – | – | – | – | 0.13 to 8 | – | – | – |
| A. fumigatus (23) | – | – | – | – | – | 0.13 to 8 | – | – | – | |
|
| ||||||||||
| Lalitha et al., 20076 | Aspergillus spp. (41) | 32 | >32 | – | 0.25 | 0.5 | – | 2 | 4 | – |
|
| ||||||||||
| Lalitha et al., 200819 | Aspergillus spp. (59) | – | – | 1 to 64 | – | – | – | – | – | – |
| A. flavus (32) | 32 | 64 | 8 to 64 | – | – | – | – | – | – | |
| A. fumigatus (18) | 4 | 4 | 1 to 4 | – | – | – | – | – | – | |
|
| ||||||||||
| Lalitha et al., 20127 | Aspergillus spp. (17) | 32 | 32 | 2 to 32 | 1 | 1 | 0.13 to 2 | – | – | – |
| A. flavus (11) | 32 | 32 | – | 1 | 1 | – | – | – | – | |
| A. fumigatus (5) | 4 | 8 | – | 0.5 | 0.5 | – | – | – | – | |
|
| ||||||||||
| Manikandan et al., 201310 |
A. flavus (74) | 128 | 128 | 4 to 128 | 0.5 | 1 | 0.25 to 1 | 2 | 8 | 0.5 to 16 |
| A. fumigatus (14) | 4 | 16 | 4 to 64 | 0.5 | 0.5 | 0.1 to 1 | 0.5 | 1 | 0.25 to 1 | |
|
| ||||||||||
| Nayak et al., 201128 | A. flavus (64) | – | – | – | – | – | – | 3.12 | 12.5 | 0.03 to 25 |
| A. fumigatus (43) | – | – | – | – | – | – | 3.12 | 3.12 | 0.03 to 12.5 |
|
|
| ||||||||||
| Pradhan et al., 201112, d | Aspergillus spp. (24) | – | – | 2 to 32 | – | – | – | – | – | – |
|
| ||||||||||
| A. flavus (13) | – | – | 8 to 32 | – | – | – | – | – | – | |
| A. fumigatus (9) | – | – | 2 to 8 | – | – | – | – | – | – | |
|
| ||||||||||
| Shapiro et al., 201011 | Aspergillus spp. (24) | 32 | 64 | 8 to 64 | – | – | – | – | – | – |
| A. flavus (18) | 32 | 64 | 16 to 64 | – | – | – | – | – | – | |
| A. fumigatus (1) | – | – | 8 | – | – | – | – | – | – | |
|
| ||||||||||
| Wang et al., 200921 | Aspergillus spp. (15) | – | – | – | – | – | – | 1 | 1 | 0.25 to 1 |
|
| ||||||||||
| Xie et al., 200827 | A. flavus (9) | – | – | – | – | – | – | 2 | 4 | – |
| A. fumigatus (9) | – | – | – | – | – | – | 1 | 2 | – | |
|
| ||||||||||
| Total Range | Aspergillus spp. | 32 |
32 to
64 |
1 to 64 |
0.25
to 1 |
0.5 to
1 |
0.13 to 8 | 1 to 2 | 1 to 4 | 0.25 to 1 |
|
| ||||||||||
| A. flavus |
32 to
128 |
32 to
128 |
4 to 128 |
0.5 to
1 |
1 | 0.25 to 1 |
2 to
3.12 |
4 to
12.5 |
0.03 to 25 | |
|
| ||||||||||
| A. fumigatus | 4 |
4 to
16 |
1 to 64 | 0.5 | 0.5 | 0.1 to 8 |
0.5 to
3.12 |
1 to
3.12 |
0.03 to
12.5 |
|
Abbreviations: N, number; MIC, minimum inhibitory concentration; MIC50, minimum inhibitory concentration median; MIC90, minimum inhibitory concentration 90th percentile; spp., species; NAT, natamycin; VRC, voriconazole; AMB, amphotericin B.
a
Susceptibility testing was performed using Clinical and Laboratory Standards Institute (CLSI) documents M38-P, M38-A, or M38-A2, except as noted.
b
Susceptibility testing method was not specified.
c
Estimated MIC50 or MIC90 using raw data provided in the article.
d
Used natamycin eye drop (Sun Pharmaceutical Ind., Ltd, Mumbai, India) for susceptibility testing instead of standard natamycin pharmaceutical-grade powder.