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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: J Acquir Immune Defic Syndr. 2014 Feb 1;65(2):142–150. doi: 10.1097/QAI.0b013e3182a9917e

Figure 1. Codon optimization significantly alters natural HIV-1 ARFs.

Figure 1

The homology of amino acid sequences is plotted as the percent of residues that were conserved with respect to a reference, the translated TFV consensus sequence, for 1 noncodon-optimized insert (MVA/HIV62; black), 2 codon-optimized inserts (VRCrAd5, MRKAd5; grey and white pattern, respectively), and the 2 wild type sequences from which the codon-optimized insert were designed (wtVRCrAd5, wtMRKAd5; grey and white). Amino acid identities were compared for all reading frames of the gag (A) and RT (B) regions.