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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: J Pediatr Surg. 2013 Oct 5;49(1):39–45. doi: 10.1016/j.jpedsurg.2013.09.024

Figure 2.

Figure 2

Figure 2

A. Western blot of protein isolated from fetal lamb lung. B. *Normalized expression of eNOS is significantly decreased in CDH lambs compared to normal lambs, p = 0.0007. **Tadalafil significantly increases eNOS expression in comparison to placebo, p = 0.0002. ***Endothelial NOS expression is significantly lower in CDH-Placebo lambs in comparison to Normal-Placebo lambs, p = 0.05, and ****eNOS expression is significantly increased in CDH-Tadalafil in comparison to CDH-Placebo, p = 0.003. There was no difference in eNOS expression between the Normal-Placebo and CDH-Tadalafil groups. C. *Normalized β-sGC expression is significantly lower in CDH lambs in comparison to normal lambs p = 0.01, and **tadalafil significantly increases β-sGC expression p = 0.0002. *** There was a trend towards decreased β-sGC expression in CDH-Placebo in comparison to Normal-Placebo, p = 0.06, but there was no significant difference in β-sGC between CDH-Placebo and CDH-Tadalafil lambs. D. There was no significant difference in normalized expression of PDE5 between groups, p = ns.