Table 2. Association of TLR SNPs with SLE in the study population (n = 795).
| Frequency | Allelic Association | Genotypic Association: Additive | Genotypic Association: Dominant | Genotypic Association: Recessive | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Position | Sample | Risk Allele | SLE (N = 795) | Normal (N = 1162) | P | OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) |
| TLR3 | |||||||||||||
| rs3775291 | Chr4 | All | G | 1036 (65.16%) | 1496 (64.37%) | 0.358 | 1.08 (0.92–1.26) | 0.359 | 1.08 (0.92–1.25) | 0.357 | 0.86 (0.63–1.18) | 0.060 | 1.23 (0.99–1.52) |
| 187004074 | Male | A | 48 (35.29%) | 352 (34.31%) | 0.999 | 1 (0.68–1.48) | 0.999 | 1 (0.67–1.49) | 0.703 | 0.9 (0.53–1.54) | 0.558 | 1.27 (0.58–2.77) | |
| Female | G | 948 (65.2%) | 822 (63.33%) | 0.305 | 1.09 (0.92–1.29) | 0.309 | 1.09 (0.92–1.29) | 0.453 | 0.88 (0.62–1.23) | 0.056 | 1.25 (1–1.58) | ||
| rs3775296 | Chr4 | All | T | 401 (25.22%) | 585 (25.17%) | 0.860 | 0.98 (0.83–1.17) | 0.859 | 0.98 (0.83–1.17) | 0.469 | 0.92 (0.75–1.14) | 0.295 | 1.26 (0.82–1.95) |
| 186997767 | Male | G | 108 (79.41%) | 756 (73.68%) | 0.254 | 1.31 (0.83–2.06) | 0.268 | 1.29 (0.83–2.01) | 0.901 | 0.94 (0.34–2.59) | 0.143 | 1.52 (0.87–2.64) | |
| Female | T | 373 (25.65%) | 315 (24.27%) | 0.727 | 1.03 (0.86–1.24) | 0.724 | 1.03 (0.86–1.25) | 0.925 | 0.99 (0.79–1.24) | 0.270 | 1.32 (0.81–2.15) | ||
| TLR7 | |||||||||||||
| rs3853839 | ChrX | All | G | 1259 (82.77%) | 1405 (77.67%) | 0.001 | 1.35 (1.13–1.62) | ||||||
| 12907658 | Male | G | 57 (85.07%) | 389 (76.13%) | 0.126 | 1.76 (0.86–3.64) | |||||||
| Female | G | 1202 (82.67%) | 1016 (78.27%) | 0.002 | 1.38 (1.12–1.69) | 0.002 | 1.38 (1.12–1.69) | 0.133 | 1.58 (0.87–2.87) | 0.003 | 1.44 (1.14–1.83) | ||
| rs5935436 | ChrX | All | T | 64 (4.2%) | 65 (3.59%) | 0.308 | 1.22 (0.83–1.77) | ||||||
| 12883891 | Male | C | 66 (97.06%) | 494 (96.3%) | 0.927 | 0.93 (0.2–4.3) | |||||||
| Female | T | 62 (4.26%) | 46 (3.54%) | 0.219 | 1.3 (0.86–1.97) | 0.219 | 1.30 (0.86–1.98) | 0.269 | 1.27 (0.83–1.95) | 0.980 | N/A | ||
| rs179010 | ChrX | All | T | 565 (37.12%) | 612 (33.81%) | 0.097 | 1.14 (0.98–1.32) | ||||||
| 12902885 | Male | T | 26 (38.24%) | 165 (32.23%) | 0.295 | 1.34 (0.78–2.32) | |||||||
| Female | T | 539 (37.07%) | 447 (34.44%) | 0.257 | 1.1 (0.93–1.3) | 0.265 | 1.1 (0.93–1.3) | 0.365 | 1.11 (0.88–1.4) | 0.349 | 1.17 (0.84–1.64) | ||
| TLR8 | |||||||||||||
| rs3764880 | ChrX | All | G | 1286 (84.55%) | 1444 (79.73%) | 0.033 | 1.23 (1.02–1.5) | ||||||
| 12924826 | Male | G | 58 (86.57%) | 377 (73.49%) | 0.054 | 2.09 (0.99–4.41) | |||||||
| Female | G | 1228 (84.46%) | 1067 (82.2%) | 0.296 | 1.12 (0.9–1.39) | 0.296 | 1.12 (0.9–1.39) | 0.781 | 1.1 (0.55–2.2) | 0.272 | 1.15 (0.9–1.47) | ||
♀For all samples, the test p-value was adjusted by age and sex; for the males and females, the test p-value was adjusted by age respectively.