Table 5. Haplotype analysis of TLR7 and TLR8 SNPs in female SLE patients and healthy controls.

	Estimated Frequency (%)			Permutation	Logistic regression		Logistic regression adjusted by age
Haplotype (rs3853839-rs5935436-rs179010-rs3764880)	All	SLE	Normal	P*	P	OR (95% CI)	P	OR (95% CI)
G-C-C-G	44.00	45.32	42.53	0.1571	0.1405	1.12 (0.96–1.30)	0.0849	1.15 (0.98–1.36)
G-C-T-G	27.47	28.27	26.58	0.2137	0.3229	1.09 (0.92–1.29)	0.6663	1.04 (0.87–1.25)
C-C-C-A	10.54	9.56	11.63	0.0742	0.0768	0.80 (0.63–1.02)	0.1279	0.82 (0.63–1.06)
C-C-C-G	7.09	5.78	8.55	0.0033	0.0049	0.66 (0.49–0.88)	0.0016	0.60 (0.44–0.82)

*p-values for estimated haplotypes were generated from 10,000 permutations using the expectation-maximization (EM) algorithm.