Table 6. Haplotype analysis of the TLR7 SNP rs3853839 and the TLR8 SNP rs3764880 in female SLE patients and healthy controls.

	Estimated Frequency (%)			Permutation	Logistic regression		Logistic regression adjusted by age
Estimated Haplotype (rs3853839-rs3764880)	All	SLE	Normal	P*	P	OR (95% CI)	P	OR (95% CI)
G-G	75.00	77.37	72.34	0.0015	0.0024	1.31 (1.10–1.55)	0.0032	1.32 (1.10–1.60)
C-A	11.01	10.25	11.86	0.2837	0.1756	0.85 (0.67–1.08)	0.2996	0.87 (0.68–1.13)
C-G	8.39	7.08	9.86	0.0073	0.0090	0.70 (0.53–0.91)	0.0014	0.62 (0.46–0.83)
G-A	5.60	5.30	5.93	0.3297	0.4677	0.89 (0.64–1.23)	0.7796	0.95 (0.67–1.35)

*p-values for estimated haplotypes were generated from 10,000 permutations using the EM algorithm.