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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Gastroenterology. 2013 Jul 25;145(5):1121–1132. doi: 10.1053/j.gastro.2013.07.025

Figure 3. Correlation of stromal compartment-specific immune cell infiltration with survival.

Figure 3

Prognostic implications upon differential immune cell infiltration for CD8+ (A-C) and FoxP3+ (D-F) cells in whole PDAC tissue (A, D), the juxtatumoral compartment (B, E) and the panstromal compartment (C, F) was determined using optimal cut-off for proportion of immune cells using X-tile software (Yale).15-17 Survival comparisons were made between patients with low (black) and high (grey) density of the immune cell infiltrate. Miller-Seigmund corrections of p-values were performed to account for multiple comparisons (Supplementary table 5). The various optimal cut-off for proportion of immune cells defining high versus low infiltrate are indicated. Patients with high densities of CD8+ in the whole PDAC tissue (A) or the juxtatumoral compartment (B) demonstrate a statistically significant survival benefit; however, this was not true for panstromal compartment (C). Lower FoxP3+ infiltration in all compartments resulted in better survival.