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Addition of cAMP organizes stochastic sparks into synchronized, rhythmic, high power, spontaneous local Ca2+ wavelets (LCR’s) in permeabilized VM. (A) Representative confocal line-scan images in control and in response to 3 μM cAMP. (B) Respective Fast Fourier Transforms (FFT), of the local Ca2+ oscillations recorded in A. (C, D) Average amplitude of Ca2+ signals of individual LCR’s and of the LCR ensembles in control and in response to cAMP. **P < 0.01, n = 9 cells.
