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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Genes Brain Behav. 2013 Dec 10;13(1):13–24. doi: 10.1111/gbb.12106

Figure 2. Gene expression patterns translate regulatory changes into networks links.

Figure 2

Gene expression patterns can change in several ways between control and disease samples, beyond standard differential expression (purple line). The variance of a gene’s expression may be altered in disease with or without differential expression (red gene expression profile) (Ho et al., 2008). Similarly altered gene-gene correlations in disease can occur with or without changes in expression (Hudson et al., 2009). A potential mechanism mediating the loss of gene-gene correlations in the disease state, through disrupted transcription factor (TF) binding, is shown on the right.