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. Author manuscript; available in PMC: 2014 Jan 21.
Published in final edited form as: Anesthesiology. 2008 Jul;109(1):137–148. doi: 10.1097/ALN.0b013e3181799d45

Figure 3. Expression of inducible nitric oxide synthase (iNOS) and tyrosine nitration in ob/ob mice and its reversal with iNOS inhibitor, L-NIL.

Figure 3

A: Immunoblot analyses (IB) revealed that iNOS expression was increased in the liver of ob/ob mice compared with wild-type (WT) mice. B: Nitrotyrosine immunoreactivity was elevated in the liver of ob/ob mice treated with phosphate buffered saline (PBS) compared with WT mice. L-NIL reduced nitrotyrosine immunoreactivity in ob/ob mice. Magnifcation: X400. C&D: The decrease in nitrotyrosine immunoreactivity observed during treatment of ob/ob mice with L-NIL was associated with improved glycemic control, evidenced as normalization of fasting blood glucose level with reduced plasma insulin concentration.