Table 4.

Inter-network intrinsic functional connectivity in patients with major depressive disorder and healthy controls.

Inter-iFC	MDD (n = 25)		HC (n = 25)		MDD vs. HCa
	Mean	SD	Mean	SD	Direction	p-value
aDMN—ipDMN	0.412	0.281	0.313	0.250	MDD > HC	0.088
aDMN—spDMN	0.340	0.247	0.131	0.244	MDD > HC	0.003
aDMN—SN	0.183	0.223	−0.020	0.248	MDD > HC	0.029
aDMN—lvCEN	0.485	0.250	0.494	0.209	HC > MDD	0.684
aDMN—rvCEN	0.410	0.231	0.380	0.191	MDD > HC	0.896
aDMN—dCEN	−0.266	0.233	−0.294	0.184	MDD > HC	0.593
ipDMN—spDMN	0.274	0.221	0.466	0.189	HC > MDD	0.062
ipDMN—SN	−0.070	0.185	−0.276	0.224	MDD > HC	0.002*
ipDMN—lvCEN	0.383	0.245	0.616	0.203	HC > MDD	0.005
ipDMN—rvCEN	0.427	0.208	0.629	0.205	HC > MDD	0.019
ipDMN—dCEN	−0.393	0.235	−0.162	0.184	HC > MDD	0.001*
spDMN—SN	0.160	0.202	−0.018	0.261	MDD > HC	0.054
spDMN—lvCEN	0.244	0.243	0.431	0.215	HC > MDD	0.080
spDMN—rvCEN	0.395	0.193	0.509	0.247	HC > MDD	0.438
spDMN—dCEN	−0.134	0.208	0.131	0.217	HC > MDD	<0.001*
SN—lvCEN	−0.044	0.173	−0.209	0.217	MDD > HC	0.027
SN—rvCEN	0.048	0.216	−0.194	0.277	MDD > HC	0.021
SN—dCEN	0.043	0.217	0.201	0.204	HC > MDD	0.026
lvCEN—rvCEN	0.580	0.248	0.602	0.202	HC > MDD	0.901
lvCEN—dCEN	−0.030	0.248	0.056	0.199	HC > MDD	0.120
rvCEN—dCEN	−0.230	0.222	−0.055	0.245	HC > MDD	0.021

^aTwo-sample t-test controlled for age, sex and total GM volume within brain areas covered by the 7 ICNs of interest.

Italics indicate p < 0.05;

^*significant for p < 0.05, Bonferroni-corrected for multiple comparisons (n = 21).

Abbreviations: MDD, group of patients with major depressive disorder; HC, healthy control group; inter-iFC, inter-network intrinsic functional connectivity; a/ip/spDMN, anterior/inferior-posterior/superior-posterior DMN; lv/rv/dCEN, left-ventral/right-ventral/dorsal CEN; SN, salience network (see also Figures 3, 4).