Fig. 1.

A deficiency of TLR9 blocks chronic restraint stress-induced lymphocyte reduction. TLR9 knockout (KO) mice or wild type (WT) Balb/c mice aged 6 to 8 weeks were subjected to a 12 h physical restraint daily. After 2 d stress, mice were sacrificed by CO2 asphyxiation, and total splenocytes were enumerated. Means and SEs were calculated from five to seven mice each group. * p < 0.01 compared with indicated groups.