Table 2.
Effects of Amitriptyline on Gastric Volumes and Emptying
| Variable | Placebo (N = 14) | AMT 25 mg (N = 14) | AMT 50 mg (N = 13) | P Value |
|---|---|---|---|---|
| Fasting volume (mL) | 259 (191, 320) | 225 (198, 286) | 257 (244, 344) | 0.32 |
| Fed volume (mL) | 797 (749, 911) | 766 (674, 858) | 845 (798, 922) | 0.38 |
| Gastric volume ratio | 3.2 (2.8, 3.3) | 3.2 (2.9, 3.7) | 2.8 (2.6, 3.6) | 0.84 |
| Postprandial change in gastric volume (mL) | 539 (465, 578) | 523 (470, 578) | 572 (515, 593) | 0.79 |
| Gastric emptying at 2 h (%) | 75 (67, 86) | 57 (49, 72) | 67 (55, 75) | 0.037 |
| Gastric emptying at 4 h (%) | 98 (97, 99) | 96 (95, 97) | 92 (91, 96) | 0.003 |
Median (1st quartile, 3rd quartile) is shown.
AMT = amitriptyline; BMI = body mass index.
Kruskal-Wallis rank sum test used for gastric emptying at 4 h; one-way analysis of variance used for all other variables.