Table 3.
Effects of Amitriptyline on Satiation Test End Points
| Variable | Placebo (N = 14) | AMT 25 mg (N = 14) | AMT 50 mg (N = 13) | P Value |
|---|---|---|---|---|
| VAS scores | ||||
| Pain | 0.9 (0.0, 4.7) | 0.8 (0.1, 1.6) | 0.8 (0.0, 1.8) | 0.82 |
| Bloating | 4.7 (3.1, 5.9) | 3.1 (2.4, 5.3) | 3.4 (2.4, 5.0) | 0.46 |
| Nausea | 2.1 (0.8, 5.3) | 0.9 (0.3, 2.3) | 0.0 (0.0, 0.5) | 0.009 |
| Fullness | 7.7 (6.9, 9.3) | 6.8 (6.4, 9.3) | 7.0 (5.0, 9.6) | 0.92 |
| Total | 16.7 (10.4, 23.5) | 13.2 (9.5, 15.4) | 12.0 (8.2, 14.8) | 0.23 |
| Volume ingested (mL) | 1,165 (1,024, 1,238) | 1,080 (919, 1,226) | 990 (900, 1,425) | 0.87 |
| Time to maximum satiation (min) | 35 (31, 38) | 34 (26, 37) | 32 (30, 42) | 0.57 |
Median (1st quartile, 3rd quartile) is shown.
AMT = amitriptyline; BMI = body mass index.
Kruskal-Wallis rank sum test used for pain, nausea and fullness VAS scores; one-way analysis of variance used for all other variables.