Table 3.

Selecting tDCS type and location: options and consequences of modulating each hemisphere

	Left hemisphere	Right hemisphere
Anodal stimulation	The lesion was large with almost no activity on any of the tasks; it would be difficult to locate an area of activity to modulate.	Right hemisphere activity may be maladaptive in that it suppresses/inhibits the normal activity of the left hemisphere; therefore we would not want to increase maladaptive activity. If the right hemisphere is now contributing significantly to his language recovery and supporting his level of communication, further up-regulation of right hemisphere activity could lead to improvements.
Cathodal stimulation	The lesion was large with almost no activity on any of the tasks; it would be difficult to locate an area of activity to modulate.	Previous research with rTMS has shown that down-regulating right hemisphere activity can lead to improvements. The right hemisphere may be contributing significantly to language recovery and may be supporting the level of communication that has been achieved, as well as artistic abilities; therefore inhibiting this activity could negatively impact current language, communication, and artistic skills.