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Aβ generation in LDLR−/− mice (A) and hAPP tg mice (B) fed either the normal chow or the high fat/cholesterol diet. The tissue extracts were prepared as described under Methods and analysed for Abet species using a sensitive ELISA. The levels of Ab42 were very low in the LDLR−/− mice. The levels of AB40 as well as 42 were very low in the normal C57BL/6 mice. * p < 0.05 versus the normally fed control group.
