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. 2013 Jun 15;8(17):1541–1550. doi: 10.3969/j.issn.1673-5374.2013.17.001

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Copyright: © Neural Regeneration Research

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Average number of neurites on spiral ganglion explants exposed to exogenous neurotrophins in solution, either on a two-dimensional (2-D) surface or in a three-dimensional (3-D) collagen gel.

Experimental groups are presented on the X axis. On 2-D collagen, neurotrophin-3 (NT-3; ^aP < 0.05), brain-derived neurotrophic factor (BDNF; ^bP < 0.001) or the two neurotrophins combined (^bP < 0.001) significantly increased neurite number when compared to media without neurotrophins (Cont). In contrast, in a 3-D gel even with both neurotrophins present, the number of neurites counted was not significantly different from that observed on explants grown on 2-D collagen without neurotrophins. The number of neurites per explant in 3-D gels was also significantly less than that observed on explants grown on 2-D surfaces with both neurotrophins (^cP < 0.05). Data are presented as mean ± SD. The number of explants in each group is provided in parentheses. Data were analyzed by analysis of variance (ANOVA) and Fisher's Protected Least Significant Difference (PLSD) post-hoc test.