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. Author manuscript; available in PMC: 2014 Jan 21.
Published in final edited form as: Annu Rev Biochem. 2011;80:973–1000. doi: 10.1146/annurev-biochem-061609-165311

Figure 3.

Figure 3

Schematics of endoplasmic reticulum (ER) distribution in yeast. (a) Yeast ER can be separated into sheet-like perinuclear ER and cortical ER structures, connected by ER tubules. The cortical ER is close to the plasma membrane (PM) and forms numerous ER-PM junctions, shown as more intense colored patches. (b) Model of the difference between cortical and perinuclear ER inheritance in yeast: (I) Distribution of cortical and perinuclear ER in cells prior to division. (II) In a first step in yeast division, organelles including vacuoles, the Golgi apparatus, and mitochondria redistribute inside the cell toward the area where the bud will appear. In the case of the ER, one tubule of the cortical ER is pulled by actin (green) and myosin into the future bud to establish contact with the PM, creating a new ER-PM junction. (III) The septin ring forms shortly after this step (purple). As the bud grows, the cortical ER is extended from the founding-bud ER-PM junction. (IV) once the nucleus is divided, the new nucleus brings along its perinuclear ER and is transferred in a microtubule-driven process into the bud. (V) The bud separates from the mother to generate a smaller daughter cell, already with separated cortical and perinuclear ER.