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. Author manuscript; available in PMC: 2014 Jan 21.
Published in final edited form as: J Pharmacokinet Pharmacodyn. 2013 Jan 12;40(2):157–176. doi: 10.1007/s10928-012-9295-8

Table 3.

Predictive performance for mouse PBPK model

Concentrations
AUC0–16ha
t1/2b
MPE%c MAPE%d MPE%c MAPE%d MPE%c MAPE%d
Plasma 28.53 43.36 16.18 16.18 9.57 12.64
Intestine −8.40 68.10 9.77 −9.77 6.09 6.09
Liver 23.57 51.03 4.10 −1.70 19.11 19.11
Kidney 45.40 52.90 8.11 8.11 18.57 18.57
Heart 52.81 73.34 18.33 13.18 15.41 15.41
Lung 4.45 59.25 24.22 −1.79 25.14 25.14
Slowly perfused 28.77 47.40 27.99 −4.53 16.24 22.96
Brain 53.30 63.65 7.30 6.24 −4.29 19.16
a

AUC0–16 h is the area under the concentration–time curve from 0 to 16 h

b

t1/2 is the half-life for elimination as calculated from linear regression of the terminal elimination phase

c

MPE% is the median prediction error, which is a measure of the bias of the prediction

d

MAPE% is the median absolute prediction error, which is a measure of the precision of the prediction