. Author manuscript; available in PMC: 2014 Feb 1.

Published in final edited form as: Acta Physiol (Oxf). 2012 Nov 26;207(2):358–368. doi: 10.1111/apha.12025

Table 3.

Maximum response (E_max) and sensitivity (logEC₅₀) to acetylcholine (ACh)- and sodium nitroprusside (SNP)-mediated vasorelaxation in aortas from SS rats on normal diet or hyper-caloric diet.

	SS-13^BN		SS
	Normal	Hyper-caloric	Normal	Hyper-caloric

	*E_max, % of PE*
ACh	85±3 (10)	86±3 (10)	56±7 (7)^*	78±4 (14)^†
+L-NAME	0.3±0.9 (10)^‡	1.4±0.9 (10)^‡	2.1±0.7 (8)^‡	-3.7±2.3 (14)^‡
SNP	95.0±1.5 (10)	96.0±0.8 (10)	91.2±3.5 (8)	94.8±2.3 (14)

	*logEC₅₀, [M]*
ACh	−7.1±0.1 (10)	−7.3±0.1 (10)	−6.9±0.1 (8)	−6.9±0.2 (13)
SNP	−8.37±0.1 (9)	−8.49±0.1 (9)	−8.0±0.2 (8)	−7.9±0.1 (13)

P<0.05 vs. aortic artery segments from SS-13^BN rats on normal diet,

^†

P<0.05 vs. aortic artery segments from SS rats on normal diet,

^‡

P<0.05 vs. corresponding untreated aortic artery segments. Number of rats is in parentheses.