Table 1. Values, units and meaning of the model parameters.

Parameter	Value	Unit	Meaning	Rationale
ap	0.154	day−1	PT cells proliferation	Fit PT
bp	16.7	day−1	PT angiogenic stimulation	Fit PT
dp	0.0717	mm−2 day−1	PT angiogenic local inhibition	H
a	0.154	day−1	Met cells proliferation	Fit Met
b	12.5	day−1	Met angiogenic stimulation	Fit Met
d	0.0717	mm−2 day−1	Met angiogenic local inhibition	H
m	0.0229	mm−3day−1	Colonization rate	Fit Met
α	2/3		Fractal dimension of vascularization	[43]
p	8.3×10−6	mg mm−3 day−1	Production of I	[26]
k	0.38	day−1	Elimination rate of I	[14]
e	7.5	mg−1day−1	Effect of I	[14]
V 0	10−6	mm3	Met initial volume	H
K 0	1	mm3	Met initial carrying capacity	[32]
Vm	1	mm3	Threshold for metastatic emission	H
D 2	0.156	mm2day−1	Angiostatin diffusion coefficient	[57]
Vd	7000	mm3	Distribution volume	H

PT = Primary Tumor. Met = metastases. I = global amount of angiogenic inhibitor in the blood. H = heuristic derivation.