. 2014 Jan 21;9(1):e84635. doi: 10.1371/journal.pone.0084635

Table 4. Summary of the effects of folic acid supplementation on all (sentinel+new) mammary tumors.

Diet group	2	5	8	10	p-value
Adenocarcinoma incidence (%)	78.6	87.8	81.8	83.2	NS
Adenoma incidence (%)	21.4	12.2	18.2	16.8	NS
Mean of all tumor weight (g)	2.0±1.2^a	3.7±1.2^b	3.2±1.2^a,b	2.9±1.2^a,b	0.03
Mean of all tumor volume (cm³)	1.8±1.2^a	3.3±1.2^b	2.6±1.2^a,b	2.5±1.2^a,b	0.04
Mean of all tumor burden (mm)	48.2±1.1	57.2±1.1	58.5±1.1	51.8±1.1	NS
Mean tumor multiplicity	3.4±0.4	4.5±0.4	4.4±0.4	3.7±0.4	NS

The secondary objective of this study was to determine the effect of folic acid supplementation on the incidence and tumor burden variables of all mammary tumors including the sentinel and new mammary adenomas and adenocarcinomas at necropsy. Diet groups represent the amount of folic acid in mg per kg diet. Results are expressed as mean ± SEM. Within each row, means with different letters significantly differ at p<0.05. All analyses were adjusted for the effects of age at randomization and days on diet.