Table 2. Comparison of the levels of proteins (pg/mL) in PPROM women with and without MIAC.
| Amniotic fluid | Cervix | Vagina | |||||||
| MIAC (n = 21) | Non-MIAC (n = 37) | p | MIAC (n = 11) | Non-MIAC (n = 22) | p | MIAC (n = 11) | Non-MIAC (n = 22) | p | |
| IL 8 | 37 (4-1429) | 6 (4-2028) | 0.016 | 239 (12-856) | 114 (8-1263) | 0.583 | 62 (4-2522) | 109 (10-666) | 0.505 |
| IL 18 | 4 (4-10) | 4 (4-8) | 0.628 | 9 (4-22) | 14 (4-446) | 0.161 | 17 (8-681) | 14 (4-1509) | 0.521 |
| CRP | 725 (15-4575) | 255 (15-2275) | 0.016 | 2970 (15-9147) | 569 (15-3920) | 0.049 | 2022 (510-3464) | 810 (15-8963) | 0.012 |
| RANTES | 31 (4-224) | 4 (4-1034) | 0.012 | 17 (4-112) | 9 (4-141) | 0.363 | 4 (4-45) | 4 (4-1106) | 0.870 |
| BDNF | 54 (10-523) | 10 (10-215) | 0.039 | 108 (10-459) | 10 (10-209) | 0.026 | 24 (10-99) | 10 (10-480) | 0.578 |
| MMP 9 | 2084 (244-37333) | 244(244-3759) | 0.578 | 18064(2425-56583) | 9538 (1518-68328) | 0.651 | 4194 (244-35816) | 7619(1048-111482) | 0.149 |
| IFN-γ | 14 (4-431) | 4 (4-288) | 0.047 | 17 (4-57) | 4 (4-24) | 0.056 | 4 (4-61) | 4 (4-151) | 0.601 |
| GM-CSF | 15 (4-43) | 4 (4-127) | 0.004 | 4 (4-29) | 4 (4-54) | 0.251 | 4 (4-85) | 8 (4-44) | 0.545 |
| sIL-6r | 798 (20-6301) | 177 (20-10554) | 0.112 | 199 (20-1327) | 76 (20-778) | 0.513 | 20 (20-1042) | 47 (20-2257) | 0.553 |
| Mip 1α | 4156 (39-7318) | 39 (39-2660) | 0.000 | 1766 (39-4147) | 559 (39-6134) | 0.143 | 539 (39-2038) | 101 (39-5675) | 0.457 |
| IL 6 | 1763 (20-3527) | 69 (20-11980) | 0.009 | 828 (20-6968) | 84 (20-616) | 0.190 | 47 (20-16694) | 20 (20-2467) | 0.578 |
| IL 10 | 564 (10-9716) | 45 (10-1403) | 0.018 | 230 (10-428) | 18 (10-715) | 0.090 | 10 (10-142) | 10 (10-764) | 0.537 |
| IL 12 | 10 (4-47) | 4 (4-28) | 0.082 | 4 (4-10) | 4 (4-32) | 0.116 | 4 (4-19) | 4 (4-26) | 0.734 |
| IL 1β | 15 (4-126) | 4 (4-641) | 0.004 | 115 (4-789) | 23 (4-421) | 0.162 | 46 (4-281) | 9 (4-1086) | 0.340 |
| TNF β | 36 (4-295) | 4 (4-214) | 0.038 | 26 (4-81) | 4 (4-121) | 0.049 | 4 (4-68) | 4 (4-259) | 0.805 |
| MCP 1 | 267 (4-3275) | 112 (4-592) | 0.060 | 342 (4-987) | 62 (10-380) | 0.071 | 84 (14-530) | 41 (4-306) | 0.059 |
| TREM 1 | 991 (98-3873) | 98 (98-2727) | 0.047 | 541 (98-1129) | 98 (98-1371) | 0.014 | 182 (98-421) | 98 (98-3983) | 1.000 |
| NT3 | 534 (4-2409) | 42 (4-909) | 0.034 | 400 (4-1262) | 64 (4-412) | 0.043 | 123 (4-260) | 69 (4-2104) | 0.427 |
| Adinopectin | 56058(500-220453) | 10971(500-106911) | 0.062 | 62850 (500-81899) | 20491 (500-99976) | 0.106 | 18971(1700-69448) | 13688(500-220672) | 0.781 |
| IGFBP1 | 2476 (461-10000) | 2329 (610-8553) | 0.967 | 5522 (3285-10000) | 4963 (670-10000) | 0.674 | 7604 (561-10000) | 5009 (869-10000) | 0.314 |
| IGFBP3 | 3774 (98-8002) | 2119 (98-22476) | 0.900 | 98 (98-902) | 98 (98-902) | 0.773 | 98 (98-2129) | 177 (98-4753) | 0.217 |
| Leptin | 1042 (98-8613) | 780 (98-20817) | 0.200 | 277 (98-420) | 98 (98-540) | 0.080 | 98 (98-402) | 98 (98-1137) | 0.760 |
| sTNF R1 | 1505 (156-5791) | 336 (156-17583) | 0.025 | 227 (156-1908) | 156 (156-1120) | 0.079 | 156 (156-1762) | 156 (156-1825) | 0.476 |
| MIF | 22189 (49-32669) | 27258 (49-48836) | 0.079 | 25819 (1153-48827) | 27480 (49-40500) | 0.948 | 28696 (49-45117) | 25252 (49-45503) | 0.597 |
MIAC: microbial invasion of the amniotic cavity. PPROM: preterm prelabor rupture of membranes. Continuous variables: Mann-Whitney U test, median (range).