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. 2014 Jan 21;9(1):e85096. doi: 10.1371/journal.pone.0085096

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© 2014 Li et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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These plots represent the correction effects of the two-step correction methods in an observed sample (CS-NA18632). (a, b, c) Performance in the RCR distribution [original (a), after correction step-1 (b), after correction step-2 (c)]. (d, e, f) Performance in coefficient of variation changement [original (d), after correction step-1 (e), after correction step-2 (f)]. (g, h, i) Performance of the RCR correction effect in the regions that have the similar GC content (i.e. 38∼42%) but different genome structure (the left box is the stable regions, the right box is the regions that close to centromeres, telomeres or N regions) [original (g), after correction step-1 (h), after correction step-2 (i)].