Table 2. Genotype/allele frequencies of rs3834129 SNP in COGENT consortium cohorts and risk of CRC (logistic regression analysis).

Cohort	Genetic model	Case (%)	Control (%)	OR	95% CI	p-value
Spanish	nor/nor	500 (25.3)	425 (25.8)	1,00
	nor/del	996 (50.3)	802 (48.7)	1,06	0.90–1.26	0,452
	del/del	482 (24.4)	420 (25.5)	0,96	0.79–1.16	0,651
	Dominant			1,03	0.88–1.20	0,730
	Recessive			0,92	0.78–1.07	0,283
	Allelic			0,98	0.89–1.08	0,658
Italian	nor/nor	195 (31.6)	783 (30.7)	1,00
	nor/del	285 (46.2)	1230 (48.2)	0,93	0.72–1.21	0,609
	del/del	137 (22.2)	538 (21.1)	0,85	0.62–1.16	0,313
	Dominant			0,91	0.71–1.15	0,432
	Recessive			0,89	0.68–1.16	0,385
	Allelic			0,92	0.79–1.08	0,306
USA	nor/nor	237 (23.5)	383 (24.2)	1,00
	nor/del	514 (50.9)	794 (50.2)	1,07	0.88–1.31	0,501
	del/del	259 (25.6)	403 (25.5)	1,04	0.83–1.32	0,678
	Dominant			1,06	0.88–1.28	0,521
	Recessive			1,00	0.83–1.20	0,984
	Allelic			1,02	0.91–1.15	0,689
English	nor/nor	410 (26.0)	165 (21.5)	1,00
	nor/del	825 (52.4)	393 (51.2)	0,79	0.62–1.00	0,051
	del/del	341 (21.6)	209 (27.3)	0,61	0.47–0.81	0,001
	Dominant			0,73	0.58–0.91	0,006
	Recessive			0,72	0.58–0.90	0,003
	Allelic			0,79	0.69–0.90	0,0006
Czech Rep.	nor/nor	239 (24.7)	169 (25.1)	1,00
	nor/del	479 (49.5)	326 (48.5)	1,04	0.82–1.34	0,724
	del/del	249 (25.7)	177 (26.3)	0,98	0.74–1.31	0,922
	Dominant			1,02	0.81–1.29	0,838
	Recessive			0,96	0.76–1.20	0,708
	Allelic			0,99	0.86–1.14	0,915
Dutch	nor/nor	169 (28.9)	106 (29.5)	1,00
	nor/del	282 (48.2)	177 (49.3)	1,00	0.74–1.36	0,996
	del/del	134 (22.9)	76 (21.2)	1,11	0.76–1.60	0,596
	Dominant			1,03	0.77–1.38	0,834
	Recessive			1,11	0.80–1.52	0,534
	Allelic			1,05	0.87–1.26	0,616