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. Author manuscript; available in PMC: 2014 Dec 26.
Published in final edited form as: Cell Rep. 2013 Dec 19;5(6):1650–1663. doi: 10.1016/j.celrep.2013.11.037

Fig. 2. LATS2 interacts with β-catenin.

Fig. 2

(A) LATS2 and β-catenin interacted when overexpressed in 293T cells.

(B) The kinase domain of LATS2 was not required for the interaction between β-catenin and LATS.

(C and D) The amino acids 250–575 of LATS2 were required for interaction with β-catenin.

(E) β-catenin-133–694 containing arm repeats interacted with LATS2. 293T cells were co-transfected with HA-LATS2 and a variety of β-catenin deletion mutants.

(F) Endogenous β-catenin interacted with LATS2 upon LiCl or Wnt-3a stimulation.

(G) GST-β-catenin fusion protein pulled down HA-LATS2 protein in vitro. See also Fig. S2.