Table 4. Surfactant homeostasis is not corrected by additional NOS2 genetic ablation.
Surfactant Fraction | |||
Small (µg) | Large (µg) | Total (µg) | |
WT (n = 7) | 76±6 | 148±10 | 224±15 |
Sftpd−/− (n = 15) | 604±39 * ξ | 249±15 * ξ | 854±49 * ξ |
DiNOS (n = 7) | 465±34 * ξ # | 233±18 * ξ | 698±42 * ξ |
NOS2−/− (n = 8) | 116±5 # | 112±6 # | 228±9 # |
Phospholipid content of BAL as well as small and large aggregate fractions was determined by the method of Bartlett. Data shown are mean ± S.E.. Statistically significant differences between groups (p<0.05) are indicated as:
vs. WT,
vs. NOS2−/−,
vs. Sftpd−/− mice.