Figure 1. HBV persistence in mice receiving HI and immunosuppressive treatment.

Mice were treated with saline or the immunosuppressive drugs DEX, CsA, CYP, or MMF from 1 week before the HI to 10 weeks after the HI, and they received the HI at w0. (A) The levels of serum HBsAg (circle) and HBV DNA (triangles) in the mice after the HI were detected using ECLIA, with the cut off values of 1.0 COI (dashed line) and 5×10² copies/ml, respectively. (B) The production of HBsAb and HBcAb in the mice was measured using ECLIA assay at w0, w7, w10, and w26 after HI. The cut off value of the HBsAb assay was 10 IU/L. The positivity of the HBcAb test was defined as inhibition >50%.