Figure 1. Involvement of oxysterols in the recruitment of neutrophils to neoplastic lesions and possible points of therapeutic intervention. (A and B) Cancer cells release oxysterols in the extracellular milieu, resulting in the recruitment of tumor-supporting neutrophils. Such neutrophils mediate pro-angiogenic effects by releasing matrix metalloproteinase 9 (MMP9) and prokineticin 2 (PROK2, also known as BV8) (A), as well as immunosuppressive functions, as they inhibit antigen-specific T cells (B). Agents that antagonize chemokine (C-X-C motif) receptor 2 (CXCR2) (A) or block oxysterols (B) may inhibit the recruitment of tumor-supporting neutrophils, hence restoring antitumor immune responses that may delay disease progression or even eradicate established lesions.