Figure 4. 1,25(OH)₂D₃ and JN protect against UV-induced edema. 1,25(OH)₂D₃ and JN reduce UV-induced edema in Skh:hr1 mouse skin. Mice were exposed to 1 × 3 MEDs (minimal erythemal doses) of solar-simulated UVR (3.98 kJ/m² UVB and 63.8 kJ/m² UVA) and were treated topically on the UV-irradiated dorsal surface immediately after UVR exposure with 100 mL of vehicle only, 1,25(OH)₂D₃, or JN. Edema was measured as dorsal skin-fold thickness in the mice 48 h after UVR exposure. Significantly different from vehicle-treated UV-irradiated mice. **p < 0.01; n = 5. Reproduced from Cancer Prevention Research. K.M. Dixon, A.W. Norman, V.B. Sequeira, R. Mohan, M.S. Rybchyn, V.E. Reeve, G.M. Halliday, R.S. Mason (2011).