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. 2014 Jan 21;9(1):e86105. doi: 10.1371/journal.pone.0086105

Figure 2. Comparisons of relative expression levels of MDL-1 and DAP12 mRNA on peripheral blood mononuclear cells (A, B; respectively) and serum levels of IL-1β, IL-6, IL-17A, and TNF-α, (C, D, E, F; respectively) are shown for 22 active RA patients, 16 inactive RA patients, 12 OA patients, and 10 healthy subjects.

Figure 2

To explore the functional role of MDL-1 activation, we examined the fold-increases of mRNA expression levels of MDL-1 and DAP12 (G, H; respectively), and the fold-increases of mRNA expression levels and supernatant levels of downstream cytokines, including IL-1β, IL-6, IL-17A, and TNF-α (I–P) on PBMCs treated with MDL-1 activator (Dengue virus type 2 [DV2]-antigen) in 6 active RA patients, 5 OA patients, and 5 healthy controls. The horizontal line indicates median value for each group. *p<0.05, **p<0.01, ***p<0.005, ****p<0.001, as determined by Mann-Whitney U test.