Table 3. Correlation between expression levels of MDL-1 and disease activity parameters as well as cytokine levels in 38 patients with rheumatoid arthritis.
Parameters | MDL-1 expression on monocytes | MDL-1 mRNA levels on PBMCs | MDL-1 protein levels on SM |
DAS28 | 0.392* | 0.428** | 0.613*** |
CRP, mg/dl | 0.289* | 0.395* | 0.596** |
Erosion score | 0.569** | 0.641*** | 0.546** |
JSN score | 0.476** | 0.484** | 0.393* |
IL-1β, pg/ml | 0.437** | 0.274* | 0.389* |
IL-6, pg/ml | 0.468** | 0.387* | 0.410* |
IL-17A, pg/ml | 0.262* | 0.280* | 0.135 |
TNF-α, pg/ml | 0.605*** | 0.459** | 0.321 |
DAP12 mRNA levels on PBMCs | 0.656*** | 0.702*** | 0.447* |
DAP12 protein levels on SM | 0.119 | 0.207 | 0.462** |
MDL-1: Myeloid DAP12-associated lectin-1; DAP12: DNAX adaptor protein 12; PBMCs: peripheral blood mononuclear cells; SM: synovial membranes; DAS28: disease activity score for 28-joints; CRP: C-reactive protein; JSN score: joint space narrowing score; IL-1β: interleukin-1β; IL-6: interleukin-6; IL-17A: interleukin-17A; TNF-α: tumor necrosis factor-α.
p<0.05, **p<0.005, ***p<0.001 were obtained by the nonparametric Spearman’s correlation test.