Figure 4. Cytokine profiles and disease features in RA patients are dependent on IFNα serum levels.

(A) Proinflammatory cytokines are increased in IFN^high patients compared with both HC and IFN^low patients. (B) Serum cytokines levels are restored in IFN^low-treated patients but not in IFN^high ones. (C) Improvement in clinical parameters in IFN^low-treated patients compared with IFN^high group. Differences between groups were assessed by Mann-Withney U-test. n. t.: non-treated; t.: treated. *p<0.05, **p<0.01, ***p<0.001.