Table 3. Comparison of the tacrolimus C 0/D in the different groups classified by genetic variant genotypes.
| Genotype | n = 240 | (days1 to 3)C0/D | p | (days6 to 8)C0/D | p | (days 12 to 14) C0/D | p |
| CYP3A5*1/*1 | 21 | 78.4±35.1 | 68.5±27.1 | 60.7±32.7 | |||
| CYP3A5*1/*3 | 103 | 76.9±37.1 | 2.93×10−9 | 72.9±41.2 | 3.87×10−13 | 65.2±33.7 | 2.79×10−14 |
| CYP3A5*3/*3 | 116 | 115.0±53.2 | 120.9±62.4 | 109.6±59.3 | |||
| CYP3A4*1/*1 | 131 | 107.7±53.2 | 111.2±62.2 | 100.5±59.7 | |||
| CYP3A4*1/*1G | 90 | 79.8±40.4 | 7.07×10−5 | 76.6±45.0 | 9.58×10−7 | 69.9±36.6 | 1.64×10−6 |
| CYP3A4*1G/*1G | 19 | 85.6±32.1 | 79.5±37.3 | 65.3±35.8 | |||
| CYP3A4 rs4646437 TT | 10 | 68.7±29.2 | 66.8±25.6 | 53.8±12.8 | |||
| CYP3A4 rs4646437 TC | 80 | 81.9±40.0 | 4.32×10−4 | 80.8±47.6 | 7.41×10−4 | 71.5±39.1 | 3.48×10−5 |
| CYP3A4 rs4646437 CC | 150 | 104.5±52.3 | 105.6±60.9 | 96.3±57.8 | |||
| POR rs1057868 CC | 101 | 96.2±45.1 | 95.4±53.6 | 84.7±52.9 | |||
| POR rs1057868 CT | 107 | 93.9±52.7 | 0.714 | 99.0±61.4 | 0.422 | 90.1±54.7 | 0.444 |
| POR rs1057868 TT | 32 | 98.3±50.2 | 85.8±52.7 | 78.3±44.9 | |||
| POR rs2868177 AA | 84 | 94.0±55.6 | 94.6±62.8 | 83.9±54.9 | |||
| POR rs2868177 AG | 104 | 93.8±43.8 | 0.471 | 93.2±54.1 | 0.411 | 83.4±40.7 | 0.471 |
| POR rs2868177 GG | 52 | 101.1±48.7 | 102.6±53.6 | 95.7±68.2 | |||
| COMT rs4646312 TT | 115 | 95.0±48.5 | 97.5±55.0 | 87.5±55.3 | |||
| COMT rs4646312 TC | 98 | 97.3±53.0 | 0.994 | 93.562.9 | 0.469 | 84.1±52.5 | 0.620 |
| COMT rs4646312 CC | 27 | 90.9±36.6 | 96.1±43.1 | 88.5±42.3 | |||
| COMT rs2239393 AA | 116 | 95.7±48.6 | 97.6±54.9 | 87.8±55.1 | |||
| COMT rs2239393 AG | 96 | 96.7±53.2 | 0.966 | 93.4±63.4 | 0.413 | 83.9±53.0 | 0.577 |
| COMT rs2239393 GG | 28 | 90.5±36.0 | 96.0±42.3 | 88.0±41.6 | |||
| COMT rs737865 TT | 126 | 94.7±47.3 | 95.4±56.2 | 86.0±57.0 | |||
| COMT rs737865 TC | 92 | 95.4±53.1 | 0.749 | 93.1±60.8 | 0.153 | 85.4±48.1 | 0.632 |
| COMT rs737865 CC | 22 | 100.0±43.1 | 108.1±45.2 | 91.5±47.3 | |||
| COMT rs6267 GG | 213 | 94.7±49.1 | 96.1±59.1 | 85.7±49.4 | |||
| COMT rs6267 GT | 26 | 102.2±50.7 | 0.775 | 93.8±37.3 | 0.646 | 91.2±76.5 | 0.972 |
| COMT rs6267 TT | 1 | 84.5 | 60.7 | 74.4 | |||
| COMT rs4680 GG | 133 | 98.9±52.6 | 96.4±58.7 | 87.2±56.5 | |||
| COMT rs4680 GA | 86 | 90.2±42.7 | 0.594 | 94.8±54.0 | 0.936 | 84.2±47.1 | 0.962 |
| COMT rs4680 AA | 21 | 95.9±50.8 | 95.3±61.0 | 88.4±51.7 | |||
| COMT rs165599 GG | 54 | 105.0±50.8 | 103.2±58.0 | 87.7±43.0 | |||
| COMT rs165599 GA | 138 | 90.3±45.4 | 0.117 | 91.4±58.7 | 0.144 | 82.6±56.7 | 0.089 |
| COMT rs165599 AA | 48 | 99.7±55.9 | 99.6±50.8 | 95.3±50.4 | |||
| IL-10 rs1800871 CC | 15 | 88.1±40.1 | 85.4±54.7 | 75.7±40.2 | |||
| IL-10 rs1800871 CT | 111 | 92.1±47.8 | 0.330 | 91.1±58.5 | 0.104 | 82.6±57.2 | 0.129 |
| IL-10 rs1800871 TT | 114 | 99.7±51.4 | 101.5±55.8 | 91.2±49.4 | |||
| IL-10 rs1800896 AA | 217 | 96.3±48.9 | 0.222 | 96.7±54.7 | 0.114 | 86.6±50.6 | 0.290 |
| IL-10 rs1800896 AG | 23 | 88.1±51.5 | 86.7±76.6 | 83.2±70.6 | |||
| IL-10 rs1800872 CC | 15 | 88.0±40.1 | 82.6±55.5 | 74.0±40.9 | |||
| IL-10 rs1800872 CA | 112 | 92.1±47.8 | 0.352 | 91.6±58.0 | 0.086 | 83.4±56.8 | 0.174 |
| IL-10 rs1800872 AA | 113 | 99.8±51.4 | 101.6±56.1 | 90.8±49.7 |