Table 3. Frequency of blood donors with mutations conferring resistance to protease inhibitors according to demographics, risk factors, subtypes, and HCV viral load.
| Total n = 125 | N (%) of resistance n = 16 | p-value | ||
| Sex | Male | 75 | 9 (12.0) | 0.37* |
| Female | 50 | 7 (14.0) | ||
| Age | 18–29 y | 33 | 5 (15.2) | 0.30* |
| 30–39 y | 45 | 4 (8.9) | ||
| 40–49 y | 28 | 6 (21.4) | ||
| >50 y | 19 | 1 (5.3) | ||
| Ethnicity | Pardo | 68 | 8 (11.8) | 0.90* |
| White | 53 | 7 (13.2) | ||
| Asian | 1 | 0 (0.0) | ||
| Missing | 3 | 1 | ||
| Education | <8 years | 20 | 1 (5.0) | 0.58* |
| Completed 8 Years | 16 | 3 (18.8) | ||
| 11 years | 66 | 8 (12.1) | ||
| Technical college | 3 | 1 (33.3) | ||
| University course | 16 | 2 (12.5) | ||
| Missing | 4 | 1 | ||
| Blood transfusion | Yes | 13 | 1 (7.7) | 0.28* |
| No | 112 | 15 (13.4) | ||
| Tattoo | Yes | 25 | 1 (4.0) | 0.10* |
| No | 78 | 10 (12.8) | ||
| Missing | 22 | 5 | ||
| Occupational exposure | Yes | 5 | 1 (20.0) | 0.29* |
| No | 101 | 12 (11.9) | ||
| Missing | 19 | 3 | ||
| Sex partner of blood transfusion recipient | Yes | 2 | 1 (50.0) | 0.05* |
| No | 103 | 12 (11.6) | ||
| Missing | 20 | 3 | ||
| Condom use | Yes | 36 | 4 (11.1) | 0.33* |
| No | 64 | 9 (14.1) | ||
| Missing | 25 | 3 | ||
| Have given or received money or drugs for sex | Yes | 13 | 2 (15.4) | 0.35* |
| No | 93 | 11 (11.8) | ||
| Missing | 19 | 3 | ||
| IVDU | Yes | 9 | 1 (11.1) | 0.45* |
| No | 97 | 12 (12.2) | ||
| Missing | 19 | 3 | ||
| HBV+ or HCV+ relatives | Yes | 19 | 4 (21.1) | 0.09* |
| No | 87 | 9 (10.3) | ||
| Missing | 19 | 3 | ||
| HCV Subtype | 1a | 50 | 10 (20.0) | 0.02* |
| 1b | 75 | 6 (8.0) | ||
| HCV RNA (log 10 UI/mL) mean | Resistant variant | 6.06 | 0.8485** | |
| Wild type | 6.32 |
*
Pearson;s chi-squared test.
**
Tukey’s t test.