Figure 5. CCR2-positive DCs have a potent capacity to induce Th1 cell differentiation.

(A) FACS of CCR2⁺ or CCR2⁻ DCs in OVA sensitized LNs. (B) Sorted DCs were co-cultured with DO11.10 Th0 cells for 72 h. Cytokines in the supernatant were measured by ELISA. Values are presented as mean ± SD (n = 4). *P<0.05, **P<0.01. (C) The expression of co-stimulation molecules in DCs was analyzed by FACS. Values are presented as mean ± SD (n = 3). **P<0.05.