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. 2014 Jan 21;9(1):e86424. doi: 10.1371/journal.pone.0086424

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© 2014 McDonald et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A. Effect of 18 Gy irradiation on cross-sectional areas in leg muscle from wild type (wt) and mdx:utrophin^+/− mice (het). *indicates significant difference from non-irradiated WT control. # indicates significant difference from non-irradiated het control. B. Effect of 18 Gy irradiation on central nucleation in leg muscle from WT and het mice. *indicates significant difference from non-irradiated WT control. # indicates significant difference from 18 Gy 7 day and 14 day het leg muscle. C. Photomicrograph of het leg muscle 60 days after gamma irradiation at 18 Gy. Arrow indicates a large group of very small myofibers. D. Photomicrograph of non-irradiated age-matched het leg muscle. Arrow indicates a myofiber with multiple centrally located myonuclei. Bar is 20 µm.