Figure 3. Kinetic curves from the multi-injection study and subsequent data simulations.

(A) Individual data points for the left hippocampus (black squares) and the olive nucleus (black circles) are plotted, with the solid lines showing the model fit in the left hippocampus, and dashed lines the model fit in the olive nucleus. Red lines show total [¹⁸F]-FMZ uptake as estimated by the model, blue lines the amount of specific [¹⁸F]-FMZ binding, and the green lines the amount of free [¹⁸F]-FMZ in the tissue. (B) Scatchard plot for parameter estimates of the hippocampus using the true free fraction for the hippocampus. (C) Scatchard plot for parameter estimates of the hippocampus using the reference region (olive nucleus).