Figure 5. Volumes of regions of interest for epileptic and control animals as measured by manual delineation on MRI.

(A) Results are expressed as volumes (number of voxels, median and inter-quartile range) in control (blue lines, n = 7) and epileptic animals (red lines, n = 8). Individual volumes are plotted for control (open squares) and epileptic animals (closed triangles). A subset of epileptic animals showed reduced hippocampal and amygdala volumes and increased ventricular volume (red triangles, n = 2) indicative of hippocampal sclerosis. Coronal slices through the hippocampi on MRI (B) a control animal, (C) an epileptic animal without hippocampal sclerosis, (D) an epileptic animal with hippocampal sclerosis. White arrows indicate decreased hippocampal volume.