Table 2.
Odds ratio (OR) and 95% confidence intervals (CI) for breast cancer by categories in circulating 25(OH)D 2 , 25(OH)D 3 , and 25(OH)D levels by race/ethnicity a
| |
White |
African-American |
Native Hawaiian |
Japanese |
Latino |
Test for heterogeneity
b
|
||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
(n = 294) |
(n = 212) |
(n = 136) |
(n = 508) |
(n = 264) |
||||||||||||||||||
| Variables and categories | No. cases/controls | OR | 95% CI | No. cases/controls | OR | 95% CI | No. cases/controls | OR | 95% CI | No. cases/controls | OR | 95% CI | No. cases/controls | OR | 95% CI | Overall | Whites vs. others | |||||
|
25(OH)D
2
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 0 ng/mL |
80/90 |
1.00 |
|
|
85/66 |
1.00 |
|
|
49/43 |
1.00 |
|
|
124/139 |
1.00 |
|
|
84/83 |
1.00 |
|
|
|
|
| > 0 ng/mL |
67/57 |
1.29 |
0.75 |
2.23 |
21/40 |
0.29 |
0.12 |
0.70 |
19/25 |
0.46 |
0.16 |
1.34 |
130/115 |
1.32 |
0.90 |
1.93 |
48/49 |
0.85 |
0.46 |
1.56 |
P = 0.817 |
P = 0.124 |
|
25(OH)D
3
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 10 ng/mL increase |
147/147 |
0.53 |
0.37 |
0.75 |
106/106 |
1.27 |
0.91 |
1.76 |
118/118 |
0.89 |
0.59 |
1.34 |
229/229 |
0.92 |
0.75 |
1.12 |
232/232 |
1.29 |
0.87 |
1.89 |
P = 0.059 |
P = 0.007 |
| 20 ng/mL increase |
147/147 |
0.28 |
0.14 |
0.56 |
106/106 |
1.61 |
0.83 |
3.11 |
118/118 |
0.80 |
0.35 |
1.79 |
229/229 |
0.84 |
0.57 |
1.24 |
232/232 |
1.65 |
0.76 |
3.57 |
|
|
|
25(OH)D |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 10 ng/mL increase |
147/147 |
0.66 |
0.48 |
0.90 |
106/106 |
1.08 |
0.79 |
1.47 |
118/118 |
0.79 |
0.52 |
1.20 |
229/229 |
1.04 |
0.84 |
1.28 |
232/232 |
1.17 |
0.84 |
1.64 |
P = 0.086 |
P = 0.051 |
| 20 ng/mL increase |
147/147 |
0.43 |
0.23 |
0.80 |
106/106 |
1.16 |
0.63 |
2.16 |
118/118 |
0.63 |
0.27 |
1.45 |
229/229 |
1.08 |
0.71 |
1.65 |
232/232 |
1.38 |
0.71 |
2.69 |
|
|
| Vitamin D deficiency |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Cutoff at 16 ng/mL |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| ≥16 ng/mL |
144/146 |
1.00 |
|
|
79/85 |
1.00 |
|
|
65/64 |
1.00 |
|
|
246/245 |
1.00 |
|
|
119/119 |
1.00 |
|
|
|
|
| <16 ng/mL |
3/1 |
4.98 |
0.40 |
62.1 |
27/21 |
1.36 |
0.59 |
3.13 |
3/4 |
1.44 |
0.18 |
11.5 |
8/9 |
0.72 |
0.24 |
2.14 |
13/13 |
1.01 |
0.31 |
3.29 |
P = 0.395 |
P = 0.465 |
| Cutoff at 20 ng/mL |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| ≥20 ng/mL |
136/145 |
1.00 |
|
|
72/70 |
1.00 |
|
|
64/61 |
1.00 |
|
|
233/231 |
1.00 |
|
|
105/102 |
1.00 |
|
|
|
|
| <20 ng/mL |
11/2 |
7.50 |
1.41 |
39.8 |
34/36 |
0.74 |
0.36 |
1.53 |
4/7 |
0.74 |
0.13 |
4.29 |
21/23 |
0.96 |
0.47 |
1.97 |
27/30 |
0.90 |
0.41 |
1.95 |
P = 0.226 |
P = 0.023 |
| Cutoff at 30 ng/mL |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| ≥30 ng/mL |
98/115 |
1.00 |
|
|
29/39 |
1.00 |
|
|
44/39 |
1.00 |
|
|
152/144 |
1.00 |
|
|
45/42 |
1.00 |
|
|
|
|
| <30 ng/mL | 49/32 | 2.56 | 1.27 | 5.14 | 77/67 | 1.34 | 0.64 | 2.79 | 24/29 | 0.64 | 0.28 | 1.49 | 102/110 | 0.86 | 0.58 | 1.29 | 87/90 | 0.76 | 0.40 | 1.46 | P = 0.025 | P = 0.026 |
Abbreviation: 25(OH)D 2 25-hydroxyvitamin D2, 25(OH)D 3 25-hydroxyvitamin D3, 25(OH)D sum of 25(OH)D2 and 25(OH)D3.
Note. Values are given in ng/mL. Multiply 2.5 to convert the values to nmol/L.
aModeled through conditional logistic regression after adjustment for season, sunburn history, body mass index, strenuous sports, number of live births, family history of breast cancer, use of multivitamin, and use of calcium supplement.
bTests based on the Wald statistic for cross-product terms between ethnicity and plasma vitamin D level.