Table 1.
Clinical Characteristics (n = 42)
| Placebo | Saxagliptin | p-value | |
|---|---|---|---|
| HbA1c (%) |
7.10 ± 0.17 |
6.84 ± 0.15 |
< 0.001 |
| Glucose postprandial (mmol/L) |
10.1 ± 0.4 |
9.27 ± 0.4 |
0.001 |
| Glucose fasting (mmol/L) |
7.49 ± 0.3 |
7.21 ± 0.3 |
0.097 |
| Adiponectin (μg/ml) |
4.58 ± 0.54 |
4.77 ± 0.59 |
0.110 |
| Insulin (pmol/L) |
88.2 ± 9.7 |
88.4 ± 9.7 |
0.975 |
| HOMA-Index |
4.21 ± 0.47 |
4.13 ± 0.49 |
0.827 |
| Office blood pressure |
|
|
|
| Systolic (mmHg) |
132 ± 2.5 |
131 ± 2.0 |
0.437 |
| Diastolic (mmHg) |
80 ± 1.3 |
79 ± 1.3 |
0.269 |
| Weight (kg) |
92.1 ± 2.6 |
92.4 ± 2.7 |
0.207 |
| Body Mass Index (kg/m2) |
30.6 ± 0.8 |
30.7 ± 0.8 |
0.233 |
| Lipids |
|
|
|
| Total cholesterol (mmol/L) |
5.41 ± 0.1 |
5.21 ± 0.1 |
0.023 |
| LDL cholesterol (mmol/L) |
3.73 ± 0.1 |
3.55 ± 0.1 |
0.015 |
| HDL cholesterol (mmol/L) |
1.24 ± 0.04 |
1.17 ± 0.04 |
< 0.001 |
| Triglycerides (mmol/L) | 1.89 ± 0.1 | 1.84 ± 0.1 | 0.602 |
HOMA-Index, Homeostasis Model Assessment.