Table 2.
Parameters of micro- and macrocirculation (n = 42)
| Placebo | Saxagliptin | p-value | |
|---|---|---|---|
|
Retinal capillary flow |
|
|
|
| RCF basal (AU) |
314 ± 14.1 |
288 ± 13.2 |
0.033 |
| RCF flicker (AU) |
331 ± 13.6 |
323 ± 16.8 |
0.462 |
| ∆ (AU) |
16.6 ± 7.9 |
32.8 ± 8.7 |
0.195 |
| ∆ (%) |
6.6 ± 2.2 |
11.4 ± 2.5 |
0.176 |
| RCF pre L-NMMA (AU) |
318 ± 11.3 |
306 ± 13.5 |
0.245 |
| RCF post L-NMMA (AU) |
318 ± 12.8 |
297 ± 13.1 |
0.116 |
| ∆ (AU) |
0.0 ± 6.9 |
- 9.0 ± 7.5 |
0.442 |
| ∆ (%) |
0.0 ± 2.1 |
- 2.1 ± 2.2 |
0.553 |
|
Retinal arteriolar structure |
|
|
|
| WLR (-) |
0.38 ± 0.01 |
0.39 ± 0.1 |
0.727 |
| WT (μm) |
14.8 ± 0.5 |
14.8 ± 0.6 |
0.987 |
| Vessel diameter (μm) |
107.7 ± 1.7 |
106.7 ± 2.0 |
0.394 |
| Lumen diameter (μm) |
78.1 ± 1.2 |
77.0 ± 1.4 |
0.256 |
|
Macrocirculation |
|
|
|
| Central SBP (mmHg) |
124 ± 2.3 |
119 ± 2.3 |
0.038 |
| Central PP (mmHg) |
45.3 ± 2.0 |
41.9 ± 2.0 |
0.058 |
| Central AP (mmHg) |
12.4 ± 0.9 |
11.0 ± 1.0 |
0.094 |
| cAIx@75 (%) |
23.0 ± 1.2 |
21.8 ± 1.3 |
0.212 |
| PWV (m/s) |
8.86 ± 0.26 |
8.56 ± 0.26 |
0.260 |
| UACR (mg/g creatinine) | 5.0 (4.0 – 12.5) | 6.0 (4.0 – 9.0) | 0.285 |
Legend: RCF, retinal capillary flow; AU, arbitrary unit; L-NMMA, NG-monomethyl-L-arginine; WLR, wall to lumen ratio; WT, wall thickness; SBP, systolic blood pressure; PP, pulse pressure; AP, augmentation pressure; cAlx@75, central augmentation index normalized to a heart rate of 75 beats/min; PWV, pulse wave velocity; UACR, urinary albumin-creatinine ratio.