Table 3.
Subgroup analysis with patients showing a decrease in postprandial blood glucose (n = 32)
| Placebo | Saxagliptin | p-value | |
|---|---|---|---|
|
Clinical characteristics |
|
|
|
| HbA1c (%) |
7.19 ± 0.2 |
6.89 ± 0.2 |
< 0.001 |
| Glucose postprandial (mmol/L) |
10.4 ± 0.4 |
9.05 ± 0.4 |
< 0.001 |
| Glucose fasting (mmol/L) |
7.60 ± 0.4 |
7.21 ± 0.3 |
0.077 |
| Office SBP (mmHg) |
132 ± 2.8 |
131 ± 2.6 |
0.564 |
| Office DBP (mmHg) |
80 ± 1.4 |
79 ± 1.4 |
0.577 |
| Weight (kg) |
90.6 ± 2.4 |
91.0 ± 2.5 |
0.162 |
| Total cholesterol (mmol/L) |
5.34 ± 0.1 |
5.08 ± 0.1 |
0.011 |
| LDL cholesterol (mmol/L) |
3.73 ± 0.1 |
3.50 ± 0.1 |
0.013 |
| HDL cholesterol (mmol/L) |
1.19 ± 0.03 |
1.14 ± 0.03 |
< 0.001 |
| Triglycerides (mmol/L) |
1.85 ± 0.2 |
1.83 ± 0.2 |
0.802 |
|
Retinal capillary flow | |||
| RCF basal (AU) |
314 ± 16.6 |
280 ± 12.1 |
0.011 |
| RCF flicker (AU) |
334 ± 16.3 |
319 ± 18.7 |
0.243 |
| ∆ (AU) |
19.1 ± 10.1 |
35.6 ± 10.9 |
0.306 |
| ∆ (%) |
7.3 ± 2.7 |
12.1 ± 3.1 |
0.299 |
| RCF pre L-NMMA (AU) |
319 ± 12.4 |
296 ± 12.3 |
0.041 |
| RCF post L-NMMA (AU) |
309 ± 12.6 |
297 ± 14.2 |
0.371 |
| ∆ (AU) |
- 9.8 ± 6.5 |
1.1 ± 8.2 |
0.344 |
| ∆ (%) |
- 2.8 ± 2.1 |
0.7 ± 2.6 |
0.339 |
|
Retinal arteriolar structure | |||
| WLR (-) |
0.38 ± 0.01 |
0.38 ± 0.02 |
0.837 |
| WT (μm) |
14.8 ± 0.6 |
14.5 ± 0.7 |
0.564 |
| Vessel diameter (μm) |
108 ± 2.1 |
106 ± 2.5 |
0.261 |
| Lumen diameter (μm) |
78 ± 1.5 |
77.4 ± 1.8 |
0.362 |
|
Macrocirculation |
|
|
|
| Central SBP (mmHg) |
123 ± 2.5 |
119 ± 2.0 |
0.080 |
| Central PP (mmHg) |
46.0 ± 2.3 |
41.9 ± 2.4 |
0.051 |
| Central AP (mmHg) |
13.3 ± 1.1 |
11.7 ± 1.1 |
0.122 |
| cAlx@75 (%) |
24.7 ± 1.3 |
23.6 ± 1.4 |
0.367 |
| PWV (m/s) |
8.39 ± 0.24 |
8.38 ± 0.27 |
0.971 |
| UACR (mg/ g creatinine) | 5.0 (4.0 – 11.0) | 6.0 (3.25 – 9.0) | 0.740 |
Legend: SBP, systolic blood pressure; DBP, diastolic blood pressure; RCF, retinal capillary flow; AU, arbitrary unit; L-NMMA, NG-monomethyl-L-arginine; WLR, wall to lumen ratio; WT, wall thickness; PP, pulse pressure; AP, augmentation pressure; cAlx@75, central augmentation index normalized to a heart rate of 75 beats/min; PWV, pulse wave velocity; UACR, urinary albumin-creatinine ratio.